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Volume 43 , Issue 3
May/June 2023
Pages 355–362

Kinetics of Phenotype Modification Therapy with VISTA: A Retrospective Case Series Using 3D Digital Analysis

Seiko Min, DDS, MS, PhD/Yen-Chun Wang, DDS/Junya Hamaguchi, DDS/Chi-Ching Chang, DDS/Taewan Kim, MS, DDS/Goncalo Carames, DDS, MS/Alfonso Gil, DDS, MS, PhD/Satoshi Yamaguchi, PhD/Satoshi Imazato, DDS, PhD/Nikola Angelov, DDS, PhD

DOI: 10.11607/prd.5621

Phenotype modification therapy has emerged as one of the main treatment objectives of periodontal plastic surgery. However, long-term data on the stability of gingival thickness gains are not available. This study examined the kinetics of mucosal thickness gain as a measure of phenotype modification therapy, following treatment of multiple gingival recession defects with vestibular incision subperiosteal tunnel access (VISTA). Six patients with 14 teeth categorized as recession type II were treated using VISTA and a subepithelial connective tissue graft (SCTG). Scanned images of study casts at pre- and postoperative periods (6 to 66 months) were digitally superimposed for quantitative evaluation of soft tissue dimensional changes. Mucosal thickness gains ranged from 1.0 ± 0.7 mm (1 mm apical to the cementoenamel junction [CEJ]) to 1.4 ± 0.4 mm (5 mm apical to the CEJ). Gingival thickness gains remained relatively stable at 66 months, with thickness gains of 0.5 ± 0.8 mm, 0.9 ± 0.6 mm, 1.1 ± 0.6 mm, 1.0 ± 0.4 mm, and 1.2 ± 0.6 mm at 1, 2, 3, 4, and 5 mm apical to the CEJ, respectively. Treatment of multiple gingival recession defects with VISTA and SCTG led to stable gingival thickness gains and shows promise as a strategy for phenotype modification therapy.

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